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Content

SECTION I

 Fuel Metabolism

  • Metabolic Fuels and Dietary Components
  • The Fed or Absorptive State
  • Fasting

 SECTION II

 Chemical and Biologic Foundations of Biochemistry

  • Water, Acids, Bases, and Buffers
  • Structures of the Major Compounds of the Body
  • Amino Acids in Proteins
  • Structure–Function Relationships in Proteins
  • Enzymes as Catalysts
  • Regulation of Enzymes
  • Cell Structure and Signaling by Chemical Messengers
  • Structure of the Nucleic Acids

 SECTION III

 Gene Expression and the Synthesis of Proteins

  • Synthesis of DNA
  • Transcription: Synthesis of RNA
  • Translation: Synthesis of Proteins
  • Regulation of Gene Expression
  • Use of Recombinant DNA Techniques in Medicine
  • The Molecular Biology of Cancer
  • An Introduction to Human Genetics

 SECTION IV

 Carbohydrate Metabolism, Fuel Oxidation, and the Generation of Adenosine Triphosphate

  • Basic Concepts in the Regulation of Fuel Metabolism by Insulin, Glucagon, and Other Hormones
  • Cellular Bioenergetics: Adenosine Triphosphate and O2
  • Digestion, Absorption, and Transport of Carbohydrates
  • Generation of Adenosine Triphosphate from Glucose, Fructose, and Galactose: Glycolysis
  • Tricarboxylic Acid Cycle
  • Oxidative Phosphorylation and Mitochondrial Function
  • Oxygen Toxicity and Free-Radical Injury
  • Formation and Degradation of Glycogen
  • Pentose Phosphate Pathway and the Synthesis of Glycosides, Lactose, Glycoproteins, and Glycolipids
  • Gluconeogenesis and Maintenance of Blood Glucose Levels

 SECTION V

 Lipid Metabolism

  • Digestion and Transport of Dietary Lipids
  • Oxidation of Fatty Acids and Ketone Bodies
  • Synthesis of Fatty Acids, Triacylglycerols, and the Major Membrane Lipids
  • Cholesterol Absorption, Synthesis, Metabolism, and Fate
  • Metabolism of Ethanol
  • Integration of Carbohydrate and Lipid Metabolism

 SECTION VI

 Nitrogen Metabolism

  • Protein Digestion and Amino Acid Absorption
  • Fate of Amino Acid Nitrogen: Urea Cycle
  • Synthesis and Degradation of Amino Acids
  • Tetrahydrofolate, Vitamin B12, and S-Adenosylmethionine
  • Purine and Pyrimidine Metabolism
  • Intertissue Relationships in the Metabolism of Amino Acids

 SECTION VII

 Tissue Metabolism

  • Actions of Hormones That Regulate Fuel Metabolism
  • The Biochemistry of Erythrocytes and Other Blood Cells
  • Blood Plasma Proteins, Coagulation, and Fibrinolysis
  • Liver Metabolism
  • Metabolism of Muscle at Rest and during Exercise
  • Metabolism of the Nervous System
  • The Extracellular Matrix and Connective Tissue

 Patient Index

 Subject Index

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